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Amplification of Mdmx and overexpression of MDM2 contribute to mammary carcinogenesis by substituting for p53 mutations

BACKGROUND: The p53 tumor suppressor gene is mutated or deleted in nearly half of human cancers. The murine double minute 2 (Mdm2) and Mdmx represent two important cellular regulators of p53. The aim of this study was to evaluate the abnormalities of p53, Mdmx and Mdm2 genes in archived breast cance...

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Detalles Bibliográficos
Autores principales:	Yu, Qiong, Li, Yan, Mu, Kun, Li, Zhishuang, Meng, Qingyong, Wu, Xiaojuan, Wang, Yan, Li, Li
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986947/ https://www.ncbi.nlm.nih.gov/pubmed/24667108 http://dx.doi.org/10.1186/1746-1596-9-71

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