Presence of antigen-specific somatic allelic mutations and splice variants do not predict for immunological response to genetic vaccination

BACKGROUND: Antigen-specific anti-tumor vaccines have demonstrated clinical efficacy, but immunological and clinical responses appear to be patient-dependent. We hypothesized that naturally-occurring differences in amino acid sequence of a host’s target antigen might predict for immunological outcom...

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Detalles Bibliográficos
Autores principales: Becker, Jordan T, McNeel, Douglas G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986973/
https://www.ncbi.nlm.nih.gov/pubmed/24764533
http://dx.doi.org/10.1186/2051-1426-1-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986973/
https://www.ncbi.nlm.nih.gov/pubmed/24764533
http://dx.doi.org/10.1186/2051-1426-1-2

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