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Presence of antigen-specific somatic allelic mutations and splice variants do not predict for immunological response to genetic vaccination
BACKGROUND: Antigen-specific anti-tumor vaccines have demonstrated clinical efficacy, but immunological and clinical responses appear to be patient-dependent. We hypothesized that naturally-occurring differences in amino acid sequence of a host’s target antigen might predict for immunological outcom...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986973/ https://www.ncbi.nlm.nih.gov/pubmed/24764533 http://dx.doi.org/10.1186/2051-1426-1-2 |