Nuclear receptor LRH-1/NR5A2 is required and targetable for liver endoplasmic reticulum stress resolution

Chronic endoplasmic reticulum (ER) stress results in toxicity that contributes to multiple human disorders. We report a stress resolution pathway initiated by the nuclear receptor LRH-1 that is independent of known unfolded protein response (UPR) pathways. Like mice lacking primary UPR components, h...

Descripción completa

Detalles Bibliográficos
Autores principales: Mamrosh, Jennifer L, Lee, Jae Man, Wagner, Martin, Stambrook, Peter J, Whitby, Richard J, Sifers, Richard N, Wu, San-Pin, Tsai, Ming-Jer, DeMayo, Francesco J, Moore, David D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2014
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987120/
https://www.ncbi.nlm.nih.gov/pubmed/24737860
http://dx.doi.org/10.7554/eLife.01694

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987120/
https://www.ncbi.nlm.nih.gov/pubmed/24737860
http://dx.doi.org/10.7554/eLife.01694

Ejemplares similares