The development of response surface pathway design to reduce animal numbers in toxicity studies

BACKGROUND: This study describes the development of Response Surface Pathway (RSP) design, assesses its performance and effectiveness in estimating LD(50,) and compares RSP with Up and Down Procedures (UDPs) and Random Walk (RW) design. METHODS: A basic 4-level RSP design was used on 36 male ICR mic...

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Detalles Bibliográficos
Autores principales: Dewi, Sagita, Aune, Tore, Bunæs, John A Aasen, Smith, Adrian J, Larsen, Stig
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987828/
https://www.ncbi.nlm.nih.gov/pubmed/24661560
http://dx.doi.org/10.1186/2050-6511-15-18

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987828/
https://www.ncbi.nlm.nih.gov/pubmed/24661560
http://dx.doi.org/10.1186/2050-6511-15-18

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