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The development of response surface pathway design to reduce animal numbers in toxicity studies
BACKGROUND: This study describes the development of Response Surface Pathway (RSP) design, assesses its performance and effectiveness in estimating LD(50,) and compares RSP with Up and Down Procedures (UDPs) and Random Walk (RW) design. METHODS: A basic 4-level RSP design was used on 36 male ICR mic...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987828/ https://www.ncbi.nlm.nih.gov/pubmed/24661560 http://dx.doi.org/10.1186/2050-6511-15-18 |