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Comparison of Efficacy of the Disease-Specific LOX1- and Constitutive Cytomegalovirus-Promoters in Expressing Interleukin 10 through Adeno-Associated Virus 2/8 Delivery in Atherosclerotic Mice

The development of gene therapy vectors for treating diseases of the cardiovascular system continues at a steady pace. Moreover, in the field of gene therapy the utility of “disease-specific promoters” has strong appeal. Many therapeutic genes, including transforming growth factor beta 1 or interleu...

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Detalles Bibliográficos
Autores principales: Zhu, Hongqing, Cao, Maohua, Mirandola, Leonardo, Figueroa, Jose A., Cobos, Everardo, Chiriva-Internati, Maurizio, Hermonat, Paul L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988062/
https://www.ncbi.nlm.nih.gov/pubmed/24736312
http://dx.doi.org/10.1371/journal.pone.0094665