Targeted Disruption of β-Arrestin 2-Mediated Signaling Pathways by Aptamer Chimeras Leads to Inhibition of Leukemic Cell Growth

β-arrestins, ubiquitous cellular scaffolding proteins that act as signaling mediators of numerous critical cellular pathways, are attractive therapeutic targets because they promote tumorigenesis in several tumor models. However, targeting scaffolding proteins with traditional small molecule drugs h...

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Detalles Bibliográficos
Autores principales: Kotula, Jonathan W., Sun, Jinpeng, Li, Margie, Pratico, Elizabeth D., Fereshteh, Mark P., Ahrens, Douglas P., Sullenger, Bruce A., Kovacs, Jeffrey J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988186/
https://www.ncbi.nlm.nih.gov/pubmed/24736311
http://dx.doi.org/10.1371/journal.pone.0093441

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988186/
https://www.ncbi.nlm.nih.gov/pubmed/24736311
http://dx.doi.org/10.1371/journal.pone.0093441

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