BAF180 Promotes Cohesion and Prevents Genome Instability and Aneuploidy

BAF180, a subunit of the PBAF chromatin remodeling complex, is frequently mutated in cancer. Although PBAF regulates transcription, it remains unclear whether this is what drives tumorigenesis in cells lacking BAF180. Based on data from yeast, we hypothesized that BAF180 may prevent tumorigenesis by...

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Detalles Bibliográficos
Autores principales: Brownlee, Peter M., Chambers, Anna L., Cloney, Ross, Bianchi, Alessandro, Downs, Jessica A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2014
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988838/
https://www.ncbi.nlm.nih.gov/pubmed/24613357
http://dx.doi.org/10.1016/j.celrep.2014.02.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988838/
https://www.ncbi.nlm.nih.gov/pubmed/24613357
http://dx.doi.org/10.1016/j.celrep.2014.02.012

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