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Tar DNA-binding protein-43 (TDP-43) regulates axon growth in vitro and in vivo()

Intracellular inclusions of the TAR-DNA binding protein 43 (TDP-43) have been reported in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD-TDP). Rare mutations in TARDBP have been linked to both ALS and FTD-TDP suggesting that TDP-43 dysfunction is mechanistic in causing disease....

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Detalles Bibliográficos
Autores principales: Tripathi, Vineeta Bhasker, Baskaran, Pranetha, Shaw, Christopher E., Guthrie, Sarah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988849/
https://www.ncbi.nlm.nih.gov/pubmed/24423647
http://dx.doi.org/10.1016/j.nbd.2014.01.004