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A Splicing-Dependent Transcriptional Checkpoint Associated with Prespliceosome Formation

There is good evidence for functional interactions between splicing and transcription in eukaryotes, but how and why these processes are coupled remain unknown. Prp5 protein (Prp5p) is an RNA-stimulated adenosine triphosphatase (ATPase) required for prespliceosome formation in yeast. We demonstrate...

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Detalles Bibliográficos
Autores principales: Chathoth, Keerthi T., Barrass, J. David, Webb, Shaun, Beggs, Jean D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988880/
https://www.ncbi.nlm.nih.gov/pubmed/24560925
http://dx.doi.org/10.1016/j.molcel.2014.01.017