Primary cilia disassembly down-regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes

OBJECTIVE: Hedgehog signalling is mediated by the primary cilium and promotes cartilage degeneration in osteoarthritis. Primary cilia are influenced by pathological stimuli and cilia length and prevalence are increased in osteoarthritic cartilage. This study aims to investigate the relationship betw...

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Detalles Bibliográficos
Autores principales: Thompson, C.L., Chapple, J.P., Knight, M.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: W.B. Saunders For The Osteoarthritis Research Society 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988976/
https://www.ncbi.nlm.nih.gov/pubmed/24457103
http://dx.doi.org/10.1016/j.joca.2013.12.016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988976/
https://www.ncbi.nlm.nih.gov/pubmed/24457103
http://dx.doi.org/10.1016/j.joca.2013.12.016

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