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Molecular Mechanism of Antibody-Mediated Activation of β-galactosidase
Binding of a single-chain Fv antibody to Escherichia coli β-galactosidase (β-gal) is known to stabilize the enzyme and activate several inactive point mutants, historically called antibody-mediated enzyme formation mutants. To understand the nature of this activation, we have determined by electron...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cell Press
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988998/ https://www.ncbi.nlm.nih.gov/pubmed/24613486 http://dx.doi.org/10.1016/j.str.2014.01.011 |