An induced rebinding model of antigen discrimination()

T cells have to detect rare high-affinity ‘foreign’ peptide MHC (pMHC) ligands among abundant low-affinity ‘self’-peptide MHC ligands. It remains unclear how this remarkable discrimination is achieved. Kinetic proofreading mechanisms can provide the required specificity but only at the expense of mu...

Descripción completa

Detalles Bibliográficos
Autores principales: Dushek, Omer, van der Merwe, P. Anton
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Ltd 2014
Materias:
Opinion
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989030/
https://www.ncbi.nlm.nih.gov/pubmed/24636916
http://dx.doi.org/10.1016/j.it.2014.02.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989030/
https://www.ncbi.nlm.nih.gov/pubmed/24636916
http://dx.doi.org/10.1016/j.it.2014.02.002

Ejemplares similares