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An induced rebinding model of antigen discrimination()
T cells have to detect rare high-affinity ‘foreign’ peptide MHC (pMHC) ligands among abundant low-affinity ‘self’-peptide MHC ligands. It remains unclear how this remarkable discrimination is achieved. Kinetic proofreading mechanisms can provide the required specificity but only at the expense of mu...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Science Ltd
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989030/ https://www.ncbi.nlm.nih.gov/pubmed/24636916 http://dx.doi.org/10.1016/j.it.2014.02.002 |