Employing novel animal models in the design of clinically efficacious GPCR ligands()

The headline success of targeting GPCRs in human diseases has masked the fact that many GPCR drug discovery programmes fail. This is despite a substantial increase in our understanding of GPCR pharmacology that has provided an array of ligands that target both orthosteric and allosteric sites as wel...

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Detalles Bibliográficos
Autores principales: Bradley, Sophie J, Riaz, Sajjad A, Tobin, Andrew B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989050/
https://www.ncbi.nlm.nih.gov/pubmed/24680437
http://dx.doi.org/10.1016/j.ceb.2013.12.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989050/
https://www.ncbi.nlm.nih.gov/pubmed/24680437
http://dx.doi.org/10.1016/j.ceb.2013.12.002

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