Multi-Kinase Inhibitor C1 Triggers Mitotic Catastrophe of Glioma Stem Cells Mainly through MELK Kinase Inhibition

Glioblastoma multiforme (GBM) is a highly lethal brain tumor. Due to resistance to current therapies, patient prognosis remains poor and development of novel and effective GBM therapy is crucial. Glioma stem cells (GSCs) have gained attention as a therapeutic target in GBM due to their relative resi...

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Detalles Bibliográficos
Autores principales: Minata, Mutsuko, Gu, Chunyu, Joshi, Kaushal, Nakano-Okuno, Mariko, Hong, Christopher, Nguyen, Chi-Hung, Kornblum, Harley I., Molla, Annie, Nakano, Ichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989164/
https://www.ncbi.nlm.nih.gov/pubmed/24739874
http://dx.doi.org/10.1371/journal.pone.0092546

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989164/
https://www.ncbi.nlm.nih.gov/pubmed/24739874
http://dx.doi.org/10.1371/journal.pone.0092546

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