Myeloid-Specific Rictor Deletion Induces M1 Macrophage Polarization and Potentiates In Vivo Pro-Inflammatory Response to Lipopolysaccharide

The phosphoinositide-3-kinase (PI3K)/protein kinase B (Akt) axis plays a central role in attenuating inflammation upon macrophage stimulation with toll-like receptor (TLR) ligands. The mechanistic target of rapamycin complex 2 (mTORC2) relays signal from PI3K to Akt but its role in modulating inflam...

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Detalles Bibliográficos
Autores principales: Festuccia, William T., Pouliot, Philippe, Bakan, Inan, Sabatini, David M., Laplante, Mathieu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989321/
https://www.ncbi.nlm.nih.gov/pubmed/24740015
http://dx.doi.org/10.1371/journal.pone.0095432

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989321/
https://www.ncbi.nlm.nih.gov/pubmed/24740015
http://dx.doi.org/10.1371/journal.pone.0095432

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