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Activation of adenosine receptor A(2A) increases HSC proliferation and inhibits death and senescence by down-regulation of p53 and Rb

Background and Aims: During fibrosis hepatic stellate cells (HSC) undergo activation, proliferation, and senescence but the regulation of these important processes is poorly understood. The adenosine A(2A) receptor (A(2A)) is known to be present on HSC, and its activation results in liver fibrosis....

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Detalles Bibliográficos
Autores principales: Ahsan, Md. Kaimul, Mehal, Wajahat Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989592/
https://www.ncbi.nlm.nih.gov/pubmed/24782773
http://dx.doi.org/10.3389/fphar.2014.00069