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Activation of adenosine receptor A(2A) increases HSC proliferation and inhibits death and senescence by down-regulation of p53 and Rb
Background and Aims: During fibrosis hepatic stellate cells (HSC) undergo activation, proliferation, and senescence but the regulation of these important processes is poorly understood. The adenosine A(2A) receptor (A(2A)) is known to be present on HSC, and its activation results in liver fibrosis....
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Frontiers Media S.A.
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989592/ https://www.ncbi.nlm.nih.gov/pubmed/24782773 http://dx.doi.org/10.3389/fphar.2014.00069 |