Three deaf mice: mouse models for TECTA-based human hereditary deafness reveal domain-specific structural phenotypes in the tectorial membrane

Tecta is a modular, non-collagenous protein of the tectorial membrane (TM), an extracellular matrix of the cochlea essential for normal hearing. Missense mutations in Tecta cause dominant forms of non-syndromic deafness and a genotype–phenotype correlation has been reported in humans, with mutations...

Descripción completa

Detalles Bibliográficos
Autores principales: Legan, P. Kevin, Goodyear, Richard J., Morín, Matías, Mencia, Angeles, Pollard, Hilary, Olavarrieta, Leticia, Korchagina, Julia, Modamio-Hoybjor, Silvia, Mayo, Fernando, Moreno, Felipe, Moreno-Pelayo, Miguel-Angel, Richardson, Guy P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3990158/
https://www.ncbi.nlm.nih.gov/pubmed/24363064
http://dx.doi.org/10.1093/hmg/ddt646

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3990158/
https://www.ncbi.nlm.nih.gov/pubmed/24363064
http://dx.doi.org/10.1093/hmg/ddt646

Ejemplares similares