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Pharmacokinetics of Zidovudine Dosed Twice Daily According to World Health Organization Weight Bands in Ugandan HIV-infected Children
Data on zidovudine pharmacokinetics in children dosed using World Health Organization weight bands are limited. About 45 HIV-infected, Ugandan children, 3.4 (2.6–6.2) years, had intensive pharmacokinetic sampling. Geometric mean zidovudine AUC(0–12h) was 3.0 h.mg/L, which is higher than previously o...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Williams & Wilkins
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3990384/ https://www.ncbi.nlm.nih.gov/pubmed/24736440 http://dx.doi.org/10.1097/INF.0000000000000143 |
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| author | Fillekes, Quirine Kendall, Lindsay Kitaka, Sabrina Mugyenyi, Peter Musoke, Philippa Ndigendawani, Milly Bwakura-Dangarembizi, Mutsa Gibb, Diana M. Burger, David Walker, Ann Sarah |
| author_facet | Fillekes, Quirine Kendall, Lindsay Kitaka, Sabrina Mugyenyi, Peter Musoke, Philippa Ndigendawani, Milly Bwakura-Dangarembizi, Mutsa Gibb, Diana M. Burger, David Walker, Ann Sarah |
| author_sort | Fillekes, Quirine |
| collection | PubMed |
| description | Data on zidovudine pharmacokinetics in children dosed using World Health Organization weight bands are limited. About 45 HIV-infected, Ugandan children, 3.4 (2.6–6.2) years, had intensive pharmacokinetic sampling. Geometric mean zidovudine AUC(0–12h) was 3.0 h.mg/L, which is higher than previously observed in adults, and was independently higher in those receiving higher doses, younger and underweight children. Higher exposure was also marginally associated with lower hemoglobin. |
| format | Online Article Text |
| id | pubmed-3990384 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2014 |
| publisher | Williams & Wilkins |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-39903842014-04-18 Pharmacokinetics of Zidovudine Dosed Twice Daily According to World Health Organization Weight Bands in Ugandan HIV-infected Children Fillekes, Quirine Kendall, Lindsay Kitaka, Sabrina Mugyenyi, Peter Musoke, Philippa Ndigendawani, Milly Bwakura-Dangarembizi, Mutsa Gibb, Diana M. Burger, David Walker, Ann Sarah Pediatr Infect Dis J HIV Reports Data on zidovudine pharmacokinetics in children dosed using World Health Organization weight bands are limited. About 45 HIV-infected, Ugandan children, 3.4 (2.6–6.2) years, had intensive pharmacokinetic sampling. Geometric mean zidovudine AUC(0–12h) was 3.0 h.mg/L, which is higher than previously observed in adults, and was independently higher in those receiving higher doses, younger and underweight children. Higher exposure was also marginally associated with lower hemoglobin. Williams & Wilkins 2014-05 2014-04-11 /pmc/articles/PMC3990384/ /pubmed/24736440 http://dx.doi.org/10.1097/INF.0000000000000143 Text en Copyright © 2014 by Lippincott Williams & Wilkins http://creativecommons.org/licenses/by-nc-nd/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivitives 3.0 License, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. |
| spellingShingle | HIV Reports Fillekes, Quirine Kendall, Lindsay Kitaka, Sabrina Mugyenyi, Peter Musoke, Philippa Ndigendawani, Milly Bwakura-Dangarembizi, Mutsa Gibb, Diana M. Burger, David Walker, Ann Sarah Pharmacokinetics of Zidovudine Dosed Twice Daily According to World Health Organization Weight Bands in Ugandan HIV-infected Children |
| title | Pharmacokinetics of Zidovudine Dosed Twice Daily According to World Health Organization Weight Bands in Ugandan HIV-infected Children |
| title_full | Pharmacokinetics of Zidovudine Dosed Twice Daily According to World Health Organization Weight Bands in Ugandan HIV-infected Children |
| title_fullStr | Pharmacokinetics of Zidovudine Dosed Twice Daily According to World Health Organization Weight Bands in Ugandan HIV-infected Children |
| title_full_unstemmed | Pharmacokinetics of Zidovudine Dosed Twice Daily According to World Health Organization Weight Bands in Ugandan HIV-infected Children |
| title_short | Pharmacokinetics of Zidovudine Dosed Twice Daily According to World Health Organization Weight Bands in Ugandan HIV-infected Children |
| title_sort | pharmacokinetics of zidovudine dosed twice daily according to world health organization weight bands in ugandan hiv-infected children |
| topic | HIV Reports |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3990384/ https://www.ncbi.nlm.nih.gov/pubmed/24736440 http://dx.doi.org/10.1097/INF.0000000000000143 |
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