Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness

Methionyl-tRNA synthetase of Trypanosoma brucei (TbMetRS) is an important target in the development of new antitrypanosomal drugs. The enzyme is essential, highly flexible and displaying a large degree of changes in protein domains and binding pockets in the presence of substrate, product and inhibi...

Descripción completa

Detalles Bibliográficos
Autores principales: Koh, Cho Yeow, Kim, Jessica E., Wetzel, Allan B., de van der Schueren, Will J., Shibata, Sayaka, Ranade, Ranae M., Liu, Jiyun, Zhang, Zhongsheng, Gillespie, J. Robert, Buckner, Frederick S., Verlinde, Christophe L. M. J., Fan, Erkang, Hol, Wim G. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3990509/
https://www.ncbi.nlm.nih.gov/pubmed/24743796
http://dx.doi.org/10.1371/journal.pntd.0002775

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3990509/
https://www.ncbi.nlm.nih.gov/pubmed/24743796
http://dx.doi.org/10.1371/journal.pntd.0002775

Ejemplares similares