Hypoxia Enhances the Antiglioma Cytotoxicity of B10, a Glycosylated Derivative of Betulinic Acid

B10 is a glycosylated derivative of betulinic acid with promising activity against glioma cells. Lysosomal cell death pathways appear to be essential for its cytotoxicity. We investigated the influence of hypoxia, nutrient deprivation and current standard therapies on B10 cytotoxicity. The human gli...

Descripción completa

Detalles Bibliográficos
Autores principales: Fischer, Sebastian, Ronellenfitsch, Michael W., Thiepold, Anna-Luisa, Harter, Patrick N., Reichert, Sebastian, Kögel, Donat, Paschke, Reinhard, Mittelbronn, Michel, Weller, Michael, Steinbach, Joachim P., Fulda, Simone, Bähr, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3990545/
https://www.ncbi.nlm.nih.gov/pubmed/24743710
http://dx.doi.org/10.1371/journal.pone.0094921

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3990545/
https://www.ncbi.nlm.nih.gov/pubmed/24743710
http://dx.doi.org/10.1371/journal.pone.0094921

Ejemplares similares