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Regulator of G Protein Signaling 2 (RGS2) and RGS4 Form Distinct G Protein-Dependent Complexes with Protease Activated-Receptor 1 (PAR1) in Live Cells

Protease-activated receptor 1 (PAR1) is a G-protein coupled receptor (GPCR) that is activated by natural proteases to regulate many physiological actions. We previously reported that PAR1 couples to G(i), G(q) and G(12) to activate linked signaling pathways. Regulators of G protein signaling (RGS) p...

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Detalles Bibliográficos
Autores principales: Ghil, Sungho, McCoy, Kelly L., Hepler, John R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3990635/
https://www.ncbi.nlm.nih.gov/pubmed/24743392
http://dx.doi.org/10.1371/journal.pone.0095355