Role of Glycogen Synthase Kinase-3β in APP Hyperphosphorylation Induced by NMDA Stimulation in Cortical Neurons

The phosphorylation of Amyloid Precursor Protein (APP) at Thr(668) plays a key role in APP metabolism that is highly relevant to AD. The c-Jun-N-terminal kinase (JNK), glycogen synthase kinase-3β (GSK-3β) and cyclin-dependent kinase 5 (Cdk5) can all be responsible for this phosphorylation. These kin...

Descripción completa

Detalles Bibliográficos
Autores principales: Ploia, Cristina, Sclip, Alessandra, Colombo, Alessio, Repici, Mariaelena, Gardoni, Fabrizio, Luca, Monica Di, Forloni, Gianluigi, Antoniou, Xanthi, Borsello, Tiziana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991020/
https://www.ncbi.nlm.nih.gov/pubmed/27713242
http://dx.doi.org/10.3390/ph3010042

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991020/
https://www.ncbi.nlm.nih.gov/pubmed/27713242
http://dx.doi.org/10.3390/ph3010042

Ejemplares similares