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Role of Glycogen Synthase Kinase-3β in APP Hyperphosphorylation Induced by NMDA Stimulation in Cortical Neurons

The phosphorylation of Amyloid Precursor Protein (APP) at Thr(668) plays a key role in APP metabolism that is highly relevant to AD. The c-Jun-N-terminal kinase (JNK), glycogen synthase kinase-3β (GSK-3β) and cyclin-dependent kinase 5 (Cdk5) can all be responsible for this phosphorylation. These kin...

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Detalles Bibliográficos
Autores principales:	Ploia, Cristina, Sclip, Alessandra, Colombo, Alessio, Repici, Mariaelena, Gardoni, Fabrizio, Luca, Monica Di, Forloni, Gianluigi, Antoniou, Xanthi, Borsello, Tiziana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Molecular Diversity Preservation International 2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991020/ https://www.ncbi.nlm.nih.gov/pubmed/27713242 http://dx.doi.org/10.3390/ph3010042

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