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Lytic Water Dynamics Reveal Evolutionarily Conserved Mechanisms of ATP Hydrolysis by TIP49 AAA+ ATPases

Eukaryotic TIP49a (Pontin) and TIP49b (Reptin) AAA+ ATPases play essential roles in key cellular processes. How their weak ATPase activity contributes to their important functions remains largely unknown and difficult to analyze because of the divergent properties of TIP49a and TIP49b proteins and o...

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Detalles Bibliográficos
Autores principales: Afanasyeva, Arina, Hirtreiter, Angela, Schreiber, Anne, Grohmann, Dina, Pobegalov, Georgii, McKay, Adam R., Tsaneva, Irina, Petukhov, Michael, Käs, Emmanuel, Grigoriev, Mikhail, Werner, Finn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991330/
https://www.ncbi.nlm.nih.gov/pubmed/24613487
http://dx.doi.org/10.1016/j.str.2014.02.002