SUMO Chain-Induced Dimerization Activates RNF4

Dimeric RING E3 ligases interact with protein substrates and conformationally restrain the ubiquitin-E2-conjugating enzyme thioester complex such that it is primed for catalysis. RNF4 is an E3 ligase containing an N-terminal domain that binds its polySUMO substrates and a C-terminal RING domain resp...

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Detalles Bibliográficos
Autores principales: Rojas-Fernandez, Alejandro, Plechanovová, Anna, Hattersley, Neil, Jaffray, Ellis, Tatham, Michael H., Hay, Ronald T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991395/
https://www.ncbi.nlm.nih.gov/pubmed/24656128
http://dx.doi.org/10.1016/j.molcel.2014.02.031

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991395/
https://www.ncbi.nlm.nih.gov/pubmed/24656128
http://dx.doi.org/10.1016/j.molcel.2014.02.031

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