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Increasing gap junction coupling suppresses ibutilide-induced torsades de pointes

Drug-induced torsades de pointes (TdP) is common with class III antiarrhythmic drugs. Increased transmural dispersion of repolarization (TDR) contributes significantly to the development of TdP. Gap junctions play an important role in maintaining TDR in long QT syndrome. The present study examined t...

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Detalles Bibliográficos
Autores principales: RUAN, LEI, QUAN, XIAOQING, LI, LIANDONG, BAI, RONG, NI, MINGKE, XU, RENDE, ZHANG, CUNTAI
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991525/
https://www.ncbi.nlm.nih.gov/pubmed/24940425
http://dx.doi.org/10.3892/etm.2014.1601