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HIV-1 Nef Inhibits Protease Activity and Its Absence Alters Protein Content of Mature Viral Particles

Nef is an important player for viral infectivity and AIDS progression, but the mechanisms involved are not completely understood. It was previously demonstrated that Nef interacts with GagPol through p6*-Protease region. Because p6* and Protease are involved in processing, we explored the effect of...

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Detalles Bibliográficos
Autores principales: Mendonça, Luiza M., Poeys, Sandro C., Abreu, Celina M., Tanuri, Amilcar, Costa, Luciana J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991643/
https://www.ncbi.nlm.nih.gov/pubmed/24748174
http://dx.doi.org/10.1371/journal.pone.0095352