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The Role of Backbone Hydrogen Bonds in the Transition State for Protein Folding of a PDZ Domain
Backbone hydrogen bonds are important for the structure and stability of proteins. However, since conventional site-directed mutagenesis cannot be applied to perturb the backbone, the contribution of these hydrogen bonds in protein folding and stability has been assessed only for a very limited set...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991670/ https://www.ncbi.nlm.nih.gov/pubmed/24748272 http://dx.doi.org/10.1371/journal.pone.0095619 |