Highly Specific Contractions of a Single CAG/CTG Trinucleotide Repeat by TALEN in Yeast

Trinucleotide repeat expansions are responsible for more than two dozens severe neurological disorders in humans. A double-strand break between two short CAG/CTG trinucleotide repeats was formerly shown to induce a high frequency of repeat contractions in yeast. Here, using a dedicated TALEN, we sho...

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Detalles Bibliográficos
Autores principales: Richard, Guy-Franck, Viterbo, David, Khanna, Varun, Mosbach, Valentine, Castelain, Lauriane, Dujon, Bernard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991675/
https://www.ncbi.nlm.nih.gov/pubmed/24748175
http://dx.doi.org/10.1371/journal.pone.0095611

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991675/
https://www.ncbi.nlm.nih.gov/pubmed/24748175
http://dx.doi.org/10.1371/journal.pone.0095611

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