TR Alpha 2 Exerts Dominant Negative Effects on Hypothalamic Trh Transcription In Vivo

Mammalian thyroid hormone receptors (TRs) have multiple isoforms, including the bona fide receptors that bind T(3) (TRα1, TRβ1 and TRβ2) and a non-hormone-binding variant, TRα2. Intriguingly, TRα2 is strongly expressed in the brain, where its mRNA levels exceed those of functional TRs. Ablation of T...

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Detalles Bibliográficos
Autores principales: Guissouma, Hajer, Ghaddab-Zroud, Rym, Seugnet, Isabelle, Decherf, Stéphanie, Demeneix, Barbara, Clerget-Froidevaux, Marie-Stéphanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991681/
https://www.ncbi.nlm.nih.gov/pubmed/24747825
http://dx.doi.org/10.1371/journal.pone.0095064

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991681/
https://www.ncbi.nlm.nih.gov/pubmed/24747825
http://dx.doi.org/10.1371/journal.pone.0095064

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