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TR Alpha 2 Exerts Dominant Negative Effects on Hypothalamic Trh Transcription In Vivo
Mammalian thyroid hormone receptors (TRs) have multiple isoforms, including the bona fide receptors that bind T(3) (TRα1, TRβ1 and TRβ2) and a non-hormone-binding variant, TRα2. Intriguingly, TRα2 is strongly expressed in the brain, where its mRNA levels exceed those of functional TRs. Ablation of T...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991681/ https://www.ncbi.nlm.nih.gov/pubmed/24747825 http://dx.doi.org/10.1371/journal.pone.0095064 |