Amphotericin forms an extramembranous and fungicidal sterol sponge

Amphotericin has remained the powerful but highly toxic last line of defense in treating life-threatening fungal infections in humans for over 50 years with minimal development of microbial resistance. Understanding how this small molecule kills yeast is thus critical for guiding development of deri...

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Detalles Bibliográficos
Autores principales: Anderson, Thomas M., Clay, Mary C., Cioffi, Alexander G., Diaz, Katrina A., Hisao, Grant S., Tuttle, Marcus D., Nieuwkoop, Andrew J., Comellas, Gemma, Maryum, Nashrah, Wang, Shu, Uno, Brice E., Wildeman, Erin L., Gonen, Tamir, Rienstra, Chad M., Burke, Martin D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992202/
https://www.ncbi.nlm.nih.gov/pubmed/24681535
http://dx.doi.org/10.1038/nchembio.1496

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992202/
https://www.ncbi.nlm.nih.gov/pubmed/24681535
http://dx.doi.org/10.1038/nchembio.1496

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