Cargando…

Amphotericin forms an extramembranous and fungicidal sterol sponge

Amphotericin has remained the powerful but highly toxic last line of defense in treating life-threatening fungal infections in humans for over 50 years with minimal development of microbial resistance. Understanding how this small molecule kills yeast is thus critical for guiding development of deri...

Descripción completa

Detalles Bibliográficos
Autores principales:	Anderson, Thomas M., Clay, Mary C., Cioffi, Alexander G., Diaz, Katrina A., Hisao, Grant S., Tuttle, Marcus D., Nieuwkoop, Andrew J., Comellas, Gemma, Maryum, Nashrah, Wang, Shu, Uno, Brice E., Wildeman, Erin L., Gonen, Tamir, Rienstra, Chad M., Burke, Martin D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992202/ https://www.ncbi.nlm.nih.gov/pubmed/24681535 http://dx.doi.org/10.1038/nchembio.1496

Ejemplares similares

Sterol Sponge Mechanism Is Conserved for Glycosylated Polyene Macrolides
por: Guo, Xiaorui, et al.
Publicado: (2021)

Enhancing Effects on Vacuole-Targeting Fungicidal Activity of Amphotericin B
por: Ogita, Akira, et al.
Publicado: (2012)

The Role of Extramembranous Cytoplasmic Termini in Assembly and Stability of the Tetrameric K(+)-Channel KcsA
por: Raja, Mobeen
Publicado: (2010)

Rampant Exchange of the Structure and Function of Extramembrane Domains between Membrane and Water Soluble Proteins
por: Nam, Hyun-Jun, et al.
Publicado: (2013)

Targeting and cytotoxicity of chimeric antigen receptor T cells grafted with PD1 extramembrane domain
por: Zhang, Ang, et al.
Publicado: (2023)

Sterols from the Madagascar Sponge Fascaplysinopsis sp
por: Aknin, Maurice, et al.
Publicado: (2010)

Formation of extramembrane β-strands controls dimerization of transmembrane helices in amyloid precursor protein C99
por: Pantelopulos, George A., et al.
Publicado: (2022)

Increasing the Fungicidal Action of Amphotericin B by Inhibiting the Nitric Oxide-Dependent Tolerance Pathway
por: Vriens, Kim, et al.
Publicado: (2017)

Neutron diffraction studies of the interaction between amphotericin B and lipid-sterol model membranes
por: Foglia, Fabrizia, et al.
Publicado: (2012)

Sterol 14α-demethylase mutation leads to amphotericin B resistance in Leishmania mexicana
por: Mwenechanya, Roy, et al.
Publicado: (2017)

Amphotericin B resistance in Leishmania mexicana: Alterations to sterol metabolism and oxidative stress response
por: Alpizar-Sosa, Edubiel A., et al.
Publicado: (2022)

Azole fungicides affect mammalian steroidogenesis by inhibiting sterol 14 alpha-demethylase and aromatase.
por: Zarn, Jürg A, et al.
Publicado: (2003)

Further thermo‐stabilization of thermophilic rhodopsin from Thermus thermophilus JL‐18 through engineering in extramembrane regions
por: Akiyama, Tomoki, et al.
Publicado: (2020)

Zn(2+) and Cu(2+) Binding to the Extramembrane Loop of Zrt2, a Zinc Transporter of Candida albicans
por: Bellotti, Denise, et al.
Publicado: (2022)

Sterol Ring System Oxidation Pattern in Marine Sponges
por: Sarma, Nittala S., et al.
Publicado: (2005)

Antibiotic-sterol interactions provide insight into the selectivity of natural aromatic analogues of amphotericin B and their photoisomers
por: Borzyszkowska-Bukowska, Julia, et al.
Publicado: (2023)

Transcriptome analysis of fungicide-responsive gene expression profiles in two Penicillium italicum strains with different response to the sterol demethylation inhibitor (DMI) fungicide prochloraz
por: Zhang, Tingfu, et al.
Publicado: (2020)

Pd@Ag Nanosheets in Combination with Amphotericin B Exert a Potent Anti-Cryptococcal Fungicidal Effect
por: Zhang, Chao, et al.
Publicado: (2016)

Genomic instability at the locus of sterol C24-methyltransferase promotes amphotericin B resistance in Leishmania parasites
por: Pountain, Andrew W., et al.
Publicado: (2019)

3,5-Dicaffeoylquinic Acid Disperses Aspergillus Fumigatus Biofilm and Enhances Fungicidal Efficacy of Voriconazole and Amphotericin B
por: Luo, Jing, et al.
Publicado: (2018)

Recognition of Membrane Sterols by Polyene Antifungals Amphotericin B and Natamycin, A (13)C MAS NMR Study
por: Ciesielski, Filip, et al.
Publicado: (2016)

Sesterterpenes and a New Sterol from the Marine Sponge Phyllospongia foliascens
por: Zhang, Hong-Jun, et al.
Publicado: (2010)

Sterols from Thai Marine Sponge Petrosia (Strongylophora) sp. and Their Cytotoxicity
por: Pailee, Phanruethai, et al.
Publicado: (2017)

Lathosterol Oxidase (Sterol C-5 Desaturase) Deletion Confers Resistance to Amphotericin B and Sensitivity to Acidic Stress in Leishmania major
por: Ning, Yu, et al.
Publicado: (2020)

Sterols of the marine sponge Petrosia weinbergi: implications for the absolute configurations of the antiviral orthoesterols and weinbersterols
por: Giner, José-Luis, et al.
Publicado: (1999)

Glycosylated Polyene Macrolides Kill Fungi via a Conserved Sterol Sponge Mechanism of Action
por: Revie, Nicole M., et al.
Publicado: (2021)

Molecular Characterization and Sterol Profiles Identify Nonsynonymous Mutations in ERG2 as a Major Mechanism Conferring Reduced Susceptibility to Amphotericin B in Candida kefyr
por: Asadzadeh, Mohammad, et al.
Publicado: (2023)

Topsensterols A–C, Cytotoxic Polyhydroxylated Sterol Derivatives from a Marine Sponge Topsentia sp.
por: Chen, Min, et al.
Publicado: (2016)

Applying the Crystalline Sponge Method to Agrochemicals: Obtaining X-ray Structures of the Fungicide Metalaxyl-M and Herbicide S-Metolachlor
por: Lunn, Richard D. J., et al.
Publicado: (2021)

Fungicides; an advanced treatise.
Publicado: (1967)

Fungicidal spectrum and biological properties of a new fungicide, pyriofenone
por: Ogawa, Munekazu, et al.
Publicado: (2023)

An Amphotericin B Derivative Equally Potent to Amphotericin B and with Increased Safety
por: Antillón, Armando, et al.
Publicado: (2016)

Encochleated Amphotericin B: Is the Oral Availability of Amphotericin B Finally Reached?
por: Aigner, Maria, et al.
Publicado: (2020)

Amphotericin-B in Dermatology
por: Agarwal, Akash, et al.
Publicado: (2022)

MIC Distributions and Evaluation of Fungicidal Activity for Amphotericin B, Itraconazole, Voriconazole, Posaconazole and Caspofungin and 20 Species of Pathogenic Filamentous Fungi Determined Using the CLSI Broth Microdilution Method
por: Borman, Andrew M., et al.
Publicado: (2017)

Amphotericin-B/amphotericin-B-liposomal: Lack of efficacy: 2 case reports
Publicado: (2022)

Foliar application of benzovindiflupyr shows non‐fungicidal effects in wheat plants
por: Kuznetsov, Dmitry, et al.
Publicado: (2017)

Discovery That Theonellasterol a Marine Sponge Sterol Is a Highly Selective FXR Antagonist That Protects against Liver Injury in Cholestasis
por: Renga, Barbara, et al.
Publicado: (2012)

Fungicide and nematicide tests
Publicado: (1999)

Principles of Fungicidal Action
por: Haley, Lenore D.
Publicado: (1957)

Cannot write session to /tmp/vufind_sessions/sess_epbrgfcu4uiodlvle9o0doabit