Aza-deoxycytidine induces apoptosis or differentiation via DNMT3B and targets embryonal carcinoma cells but not their differentiated derivatives

BACKGROUND: Teratocarcinoma is a malignant male germ cell tumour, which contains stem cells and differentiated cancer tissues. DNMT3B has been shown to be highly expressed in human teratocarcinoma stem cells, and to mediate cytotoxicity of Aza-deoxycytidine (Aza-dC) in a pluripotent stem cell line N...

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Detalles Bibliográficos
Autores principales: Wongtrakoongate, P, Li, J, Andrews, P W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Genetics & Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992495/
https://www.ncbi.nlm.nih.gov/pubmed/24603304
http://dx.doi.org/10.1038/bjc.2014.128

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992495/
https://www.ncbi.nlm.nih.gov/pubmed/24603304
http://dx.doi.org/10.1038/bjc.2014.128

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