Restoration of PPP2CA expression reverses epithelial-to-mesenchymal transition and suppresses prostate tumour growth and metastasis in an orthotopic mouse model

BACKGROUND: Emergence of castration-resistance in prostate cancer (PCa) is invariably associated with aggressive and metastatic disease. Previously, we reported promotion of castration-resistance upon downregulation of PPP2CA (encoding catalytic subunit of protein phosphatase 2A (PP2A), α-isoform);...

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Detalles Bibliográficos
Autores principales: Bhardwaj, A, Singh, S, Srivastava, S K, Arora, S, Hyde, S J, Andrews, J, Grizzle, W E, Singh, A P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992501/
https://www.ncbi.nlm.nih.gov/pubmed/24642616
http://dx.doi.org/10.1038/bjc.2014.141

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992501/
https://www.ncbi.nlm.nih.gov/pubmed/24642616
http://dx.doi.org/10.1038/bjc.2014.141

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