Cargando…

c-Jun N-terminal kinase regulates mGluR-dependent expression of post-synaptic FMRP target proteins

Fragile X syndrome (FXS) is caused by the loss of functional fragile X mental retardation protein (FMRP). Loss of FMRP results in an elevated basal protein expression profile of FMRP targeted mRNAs, a loss of local metabotropic glutamate receptor (mGluR)-regulated protein synthesis, exaggerated long...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schmit, Travis L, Dowell, James A, Maes, Margaret E, Wilhelm, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2013
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992883/ https://www.ncbi.nlm.nih.gov/pubmed/24047560 http://dx.doi.org/10.1111/jnc.12453

Ejemplares similares

FMRP Mediates mGluR(5)-Dependent Translation of Amyloid Precursor Protein
por: Westmark, Cara J, et al.
Publicado: (2007)

mGluR-Dependent Synaptic Plasticity in Drug-Seeking
por: Bellone, Camilla, et al.
Publicado: (2012)

Translational Concepts of mGluR5 in Synaptic Diseases of the Brain
por: Piers, Thomas M., et al.
Publicado: (2012)

Conformational pathway provides unique sensitivity to a synaptic mGluR
por: Habrian, Chris H., et al.
Publicado: (2019)

Modeling mGluR1 mediated synaptic depression in cerebellar Purkinje cells
por: Su, Yizhen, et al.
Publicado: (2014)

Optogenetic activation of mGluR1 signaling in the cerebellum induces synaptic plasticity
por: Surdin, Tatjana, et al.
Publicado: (2022)

mGluR5 is transiently confined in perisynaptic nanodomains to shape synaptic function
por: Scheefhals, Nicky, et al.
Publicado: (2023)

The mGluR6 ligand-binding domain, but not the C-terminal domain, is required for synaptic localization in retinal ON-bipolar cells
por: Agosto, Melina A., et al.
Publicado: (2021)

Group I mGluRs in Therapy and Diagnosis of Parkinson’s Disease: Focus on mGluR5 Subtype
por: Azam, Shofiul, et al.
Publicado: (2022)

Metabotropic glutamate receptors (mGluRs) in epileptogenesis: an update on abnormal mGluRs signaling and its therapeutic implications
por: Huang, Leyi, et al.
Publicado: (2023)

Microtransplantation of Postmortem Native Synaptic mGluRs Receptors into Xenopus Oocytes for Their Functional Analysis
por: Miller, Brice, et al.
Publicado: (2022)

mGluR5, CB1 and neuroprotection
por: Carvalho, Toniana G., et al.
Publicado: (2016)

Enhanced group II mGluR-mediated inhibition of pain-related synaptic plasticity in the amygdala
por: Han, Jeong S, et al.
Publicado: (2006)

Transduction of group I mGluR-mediated synaptic plasticity by β-arrestin2 signalling
por: Eng, Andrew G., et al.
Publicado: (2016)

The orthosteric agonist 2-chloro-5-hydroxyphenylglycine activates mGluR5 and mGluR1 with similar efficacy and potency
por: Kammermeier, Paul J
Publicado: (2012)

The Changes in mGluR2 and mGluR7 Expression in Rat Medial Vestibular Nucleus and Flocculus Following Unilateral Labyrinthectomy
por: Zhou, Wen, et al.
Publicado: (2013)

Pretreatment with mGluR2 or mGluR3 Agonists Reduces Apoptosis Induced by Hypoxia-Ischemia in Neonatal Rat Brains
por: Bratek - Gerej, Ewelina, et al.
Publicado: (2021)

mRNA and protein expression for novel GABA(A) receptors θ and ρ2 are altered in schizophrenia and mood disorders; relevance to FMRP-mGluR5 signaling pathway
por: Fatemi, S H, et al.
Publicado: (2013)

mGluR5 Is Substitutable for mGluR1 in Cerebellar Purkinje Cells for Motor Coordination, Developmental Synapse Elimination, and Motor Learning
por: Harbers, Maria, et al.
Publicado: (2022)

mGluR5 mediates post-radiotherapy fatigue development in cancer patients
por: Feng, Li Rebekah, et al.
Publicado: (2018)

Investigating the role of mGluR2 versus mGluR3 in antipsychotic-like effects, sleep-wake architecture and network oscillatory activity using novel Han Wistar rats lacking mGluR2 expression
por: Wood, Christian M., et al.
Publicado: (2018)

Does the MK2-dependent Production of TNFα Regulate mGluR-dependent Synaptic Plasticity?
por: Hogg, Ellen L., et al.
Publicado: (2016)

Abnormal mGluR-mediated synaptic plasticity and autism-like behaviours in Gprasp2 mutant mice
por: Edfawy, Mohamed, et al.
Publicado: (2019)

The Golgi-Associated PDZ Domain Protein Gopc/PIST Is Required for Synaptic Targeting of mGluR5
por: Klüssendorf, Malte, et al.
Publicado: (2021)

The regulatory role of NAAG-mGluR3 signaling on cortical synaptic plasticity after hypoxic ischemia
por: Li, Kexin, et al.
Publicado: (2022)

Transient astrocytic mGluR5 expression drives synaptic plasticity and subsequent chronic pain in mice
por: Danjo, Yosuke, et al.
Publicado: (2022)

PET imaging of mGluR5 in Alzheimer’s disease
por: Mecca, Adam P., et al.
Publicado: (2020)

Transgenerational deep sequencing revealed hypermethylation of hippocampal mGluR1 gene with altered mRNA expression of mGluR5 and mGluR3 associated with behavioral changes in Sprague Dawley rats with history of prolonged febrile seizure
por: Alese, Oluwole Ojo, et al.
Publicado: (2019)

Extinction-Dependent Alterations in Corticostriatal mGluR2/3 and mGluR7 Receptors following Chronic Methamphetamine Self-Administration in Rats
por: Schwendt, Marek, et al.
Publicado: (2012)

Opposite Effects of mGluR1a and mGluR5 Activation on Nucleus Accumbens Medium Spiny Neuron Dendritic Spine Density
por: Gross, Kellie S., et al.
Publicado: (2016)

Target validation: Weak selectivity of LY341495 for mGluR2 over mGluR4 makes glutamate a less selective agonist
por: McCullock, Tyler W., et al.
Publicado: (2019)

Synaptic depression via mGluR1 positive allosteric modulation suppresses cue-induced cocaine craving
por: Loweth, Jessica A., et al.
Publicado: (2013)

Two routes to autism phenotypes via mGluR5
Publicado: (2012)

Therapeutic potential of mGluR5 targeting in Alzheimer's disease
por: Kumar, Anil, et al.
Publicado: (2015)

mGluR5 hypofunction is integral to glutamatergic dysregulation in schizophrenia
por: Wang, Hoau-Yan, et al.
Publicado: (2018)

Neuromodulation by mGluRs in Sound Localization Circuits in the Auditory Brainstem
por: Goel, Nupur, et al.
Publicado: (2020)

Reduced mGluR5 Activity Modulates Mitochondrial Function
por: Gonzalez-Lozano, Miguel A., et al.
Publicado: (2021)

Selective Recruitment of Presynaptic and Postsynaptic Forms of mGluR-LTD
por: Sanderson, Thomas M., et al.
Publicado: (2022)

Role for Astrocytes in mGluR-Dependent LTD in the Neocortex and Hippocampus
por: Lalo, Ulyana, et al.
Publicado: (2022)

mGluR-dependent plasticity in rodent models of Alzheimer’s disease
por: Valdivia, Gonzalo, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_dcoisrpksbrc95re0ohs6tq3ta