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Fast Alpha Nucleophiles: Structures that Undergo Rapid Hydrazone/Oxime Formation at Neutral pH

[Image: see text] Hydrazones and oximes are widely useful structures for conjugate formation in chemistry and biology, but their formation can be slow at neutral pH. Kinetics studies were performed for a range of structurally varied hydrazines, and a surprisingly large variation in reaction rate was...

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Detalles Bibliográficos
Autores principales: Kool, Eric T., Crisalli, Pete, Chan, Ke Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993714/
https://www.ncbi.nlm.nih.gov/pubmed/24559274
http://dx.doi.org/10.1021/ol500262y