A Homologation Approach to the Synthesis of Difluorinated Cycloalkynes

[Image: see text] Difluorinated cyclooctynes are important reagents for labeling azido-biomolecules through copper-free click chemistry. Here, a safe, scalable synthesis of a difluorinated cyclooctyne is reported, which involves a key homologation/ring-expansion reaction. Sequential ring expansions...

Descripción completa

Detalles Bibliográficos
Autores principales: Sletten, Ellen M., de Almeida, Gabriela, Bertozzi, Carolyn R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993865/
https://www.ncbi.nlm.nih.gov/pubmed/24588780
http://dx.doi.org/10.1021/ol500260d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993865/
https://www.ncbi.nlm.nih.gov/pubmed/24588780
http://dx.doi.org/10.1021/ol500260d

Ejemplares similares