A Homologation Approach to the Synthesis of Difluorinated Cycloalkynes

[Image: see text] Difluorinated cyclooctynes are important reagents for labeling azido-biomolecules through copper-free click chemistry. Here, a safe, scalable synthesis of a difluorinated cyclooctyne is reported, which involves a key homologation/ring-expansion reaction. Sequential ring expansions...

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Autores principales: Sletten, Ellen M., de Almeida, Gabriela, Bertozzi, Carolyn R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993865/
https://www.ncbi.nlm.nih.gov/pubmed/24588780
http://dx.doi.org/10.1021/ol500260d
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author Sletten, Ellen M.
de Almeida, Gabriela
Bertozzi, Carolyn R.
author_facet Sletten, Ellen M.
de Almeida, Gabriela
Bertozzi, Carolyn R.
author_sort Sletten, Ellen M.
collection PubMed
description [Image: see text] Difluorinated cyclooctynes are important reagents for labeling azido-biomolecules through copper-free click chemistry. Here, a safe, scalable synthesis of a difluorinated cyclooctyne is reported, which involves a key homologation/ring-expansion reaction. Sequential ring expansions were also employed to synthesize and study a novel difluorinated cyclononyne.
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spelling pubmed-39938652015-03-03 A Homologation Approach to the Synthesis of Difluorinated Cycloalkynes Sletten, Ellen M. de Almeida, Gabriela Bertozzi, Carolyn R. Org Lett [Image: see text] Difluorinated cyclooctynes are important reagents for labeling azido-biomolecules through copper-free click chemistry. Here, a safe, scalable synthesis of a difluorinated cyclooctyne is reported, which involves a key homologation/ring-expansion reaction. Sequential ring expansions were also employed to synthesize and study a novel difluorinated cyclononyne. American Chemical Society 2014-03-03 2014-03-21 /pmc/articles/PMC3993865/ /pubmed/24588780 http://dx.doi.org/10.1021/ol500260d Text en Copyright © 2014 American Chemical Society
spellingShingle Sletten, Ellen M.
de Almeida, Gabriela
Bertozzi, Carolyn R.
A Homologation Approach to the Synthesis of Difluorinated Cycloalkynes
title A Homologation Approach to the Synthesis of Difluorinated Cycloalkynes
title_full A Homologation Approach to the Synthesis of Difluorinated Cycloalkynes
title_fullStr A Homologation Approach to the Synthesis of Difluorinated Cycloalkynes
title_full_unstemmed A Homologation Approach to the Synthesis of Difluorinated Cycloalkynes
title_short A Homologation Approach to the Synthesis of Difluorinated Cycloalkynes
title_sort homologation approach to the synthesis of difluorinated cycloalkynes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993865/
https://www.ncbi.nlm.nih.gov/pubmed/24588780
http://dx.doi.org/10.1021/ol500260d
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