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A Homologation Approach to the Synthesis of Difluorinated Cycloalkynes

[Image: see text] Difluorinated cyclooctynes are important reagents for labeling azido-biomolecules through copper-free click chemistry. Here, a safe, scalable synthesis of a difluorinated cyclooctyne is reported, which involves a key homologation/ring-expansion reaction. Sequential ring expansions...

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Detalles Bibliográficos
Autores principales:	Sletten, Ellen M., de Almeida, Gabriela, Bertozzi, Carolyn R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993865/ https://www.ncbi.nlm.nih.gov/pubmed/24588780 http://dx.doi.org/10.1021/ol500260d

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