Direct Access to Functionalized Azepanes by Cross-Coupling with α-Halo Eneformamides

[Image: see text] The synthesis of functionalized azepanes was accomplished through the palladium-mediated cross-coupling of α-halo eneformamides with mostly unactivated nucleophiles under mild conditions. Alkenylations proceeded with excellent stereoselectivitiy. In most cases, high yields of the c...

Descripción completa

Detalles Bibliográficos
Autores principales: Beng, Timothy K., Wilkerson-Hill, Sidney M., Sarpong, Richmond
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993866/
https://www.ncbi.nlm.nih.gov/pubmed/24456197
http://dx.doi.org/10.1021/ol403671s
Descripción
Sumario:[Image: see text] The synthesis of functionalized azepanes was accomplished through the palladium-mediated cross-coupling of α-halo eneformamides with mostly unactivated nucleophiles under mild conditions. Alkenylations proceeded with excellent stereoselectivitiy. In most cases, high yields of the coupling products were obtained.

Ejemplares similares