Direct Access to Functionalized Azepanes by Cross-Coupling with α-Halo Eneformamides

[Image: see text] The synthesis of functionalized azepanes was accomplished through the palladium-mediated cross-coupling of α-halo eneformamides with mostly unactivated nucleophiles under mild conditions. Alkenylations proceeded with excellent stereoselectivitiy. In most cases, high yields of the c...

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Autores principales: Beng, Timothy K., Wilkerson-Hill, Sidney M., Sarpong, Richmond
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993866/
https://www.ncbi.nlm.nih.gov/pubmed/24456197
http://dx.doi.org/10.1021/ol403671s
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author Beng, Timothy K.
Wilkerson-Hill, Sidney M.
Sarpong, Richmond
author_facet Beng, Timothy K.
Wilkerson-Hill, Sidney M.
Sarpong, Richmond
author_sort Beng, Timothy K.
collection PubMed
description [Image: see text] The synthesis of functionalized azepanes was accomplished through the palladium-mediated cross-coupling of α-halo eneformamides with mostly unactivated nucleophiles under mild conditions. Alkenylations proceeded with excellent stereoselectivitiy. In most cases, high yields of the coupling products were obtained.
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spelling pubmed-39938662015-01-23 Direct Access to Functionalized Azepanes by Cross-Coupling with α-Halo Eneformamides Beng, Timothy K. Wilkerson-Hill, Sidney M. Sarpong, Richmond Org Lett [Image: see text] The synthesis of functionalized azepanes was accomplished through the palladium-mediated cross-coupling of α-halo eneformamides with mostly unactivated nucleophiles under mild conditions. Alkenylations proceeded with excellent stereoselectivitiy. In most cases, high yields of the coupling products were obtained. American Chemical Society 2014-01-23 2014-02-07 /pmc/articles/PMC3993866/ /pubmed/24456197 http://dx.doi.org/10.1021/ol403671s Text en Copyright © 2014 American Chemical Society
spellingShingle Beng, Timothy K.
Wilkerson-Hill, Sidney M.
Sarpong, Richmond
Direct Access to Functionalized Azepanes by Cross-Coupling with α-Halo Eneformamides
title Direct Access to Functionalized Azepanes by Cross-Coupling with α-Halo Eneformamides
title_full Direct Access to Functionalized Azepanes by Cross-Coupling with α-Halo Eneformamides
title_fullStr Direct Access to Functionalized Azepanes by Cross-Coupling with α-Halo Eneformamides
title_full_unstemmed Direct Access to Functionalized Azepanes by Cross-Coupling with α-Halo Eneformamides
title_short Direct Access to Functionalized Azepanes by Cross-Coupling with α-Halo Eneformamides
title_sort direct access to functionalized azepanes by cross-coupling with α-halo eneformamides
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993866/
https://www.ncbi.nlm.nih.gov/pubmed/24456197
http://dx.doi.org/10.1021/ol403671s
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