Improved Total Synthesis and Biological Evaluation of Potent Apratoxin S4 Based Anticancer Agents with Differential Stability and Further Enhanced Activity

[Image: see text] Apratoxins are cytotoxic natural products originally isolated from marine cyanobacteria that act by preventing cotranslational translocation early in the secretory pathway to downregulate receptor levels and inhibit growth factor secretion, leading to potent antiproliferative activ...

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Detalles Bibliográficos
Autores principales: Chen, Qi-Yin, Liu, Yanxia, Cai, Weijing, Luesch, Hendrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993931/
https://www.ncbi.nlm.nih.gov/pubmed/24660812
http://dx.doi.org/10.1021/jm4019965

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993931/
https://www.ncbi.nlm.nih.gov/pubmed/24660812
http://dx.doi.org/10.1021/jm4019965

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