Cargando…

Improved Total Synthesis and Biological Evaluation of Potent Apratoxin S4 Based Anticancer Agents with Differential Stability and Further Enhanced Activity

[Image: see text] Apratoxins are cytotoxic natural products originally isolated from marine cyanobacteria that act by preventing cotranslational translocation early in the secretory pathway to downregulate receptor levels and inhibit growth factor secretion, leading to potent antiproliferative activ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Qi-Yin, Liu, Yanxia, Cai, Weijing, Luesch, Hendrik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993931/ https://www.ncbi.nlm.nih.gov/pubmed/24660812 http://dx.doi.org/10.1021/jm4019965

Ejemplares similares

Systematic Chemical Mutagenesis Identifies a Potent Novel Apratoxin A/E Hybrid with Improved in Vivo Antitumor Activity
por: Chen, Qi-Yin, et al.
Publicado: (2011)

Inhibition of cotranslational translocation by apratoxin S4: Effects on oncogenic receptor tyrosine kinases and the fate of transmembrane proteins produced in the cytoplasm
por: Cai, Weijing, et al.
Publicado: (2021)

Sec61 Inhibitor Apratoxin S4 Potently Inhibits SARS-CoV-2 and Exhibits Broad-Spectrum Antiviral Activity
por: Pohl, Marie O., et al.
Publicado: (2022)

Apratoxin chaperones EGFR to its destruction
por: Short, Ben
Publicado: (2009)

Green synthesis and biological evaluation of novel 5-fluorouracil derivatives as potent anticancer agents
por: Jubeen, Farhat, et al.
Publicado: (2019)

Design and synthesis of novel oridonin analogues as potent anticancer agents
por: Shen, Qing-Kun, et al.
Publicado: (2018)

ATG5 Promotes Death Signaling in Response to the Cyclic Depsipeptides Coibamide A and Apratoxin A
por: Wan, Xuemei, et al.
Publicado: (2018)

Synthesis and Biological Evaluation of Novel Triple-Modified Colchicine Derivatives as Potent Tubulin-Targeting Anticancer Agents
por: Majcher, Urszula, et al.
Publicado: (2018)

Biological Evaluation of Noscapine analogues as Potent and Microtubule-Targeted Anticancer Agents
por: Tomar, Vartika, et al.
Publicado: (2019)

A Highly Potent Class of Halogenated Phenazine Antibacterial and Biofilm-Eradicating Agents Accessed Through a Modular Wohl-Aue Synthesis
por: Yang, Hongfen, et al.
Publicado: (2017)

Synthesis, Biological Activity, ADME and Molecular Docking Studies of Novel Ursolic Acid Derivatives as Potent Anticancer Agents
por: Michalak, Olga, et al.
Publicado: (2023)

Hexafluoroisopropanol-Mediated Domino Reaction for the Synthesis of Thiazolo-androstenones: Potent Anticancer Agents
por: Okolo, ChrisTina, et al.
Publicado: (2018)

Single Cell Genome Amplification Accelerates Identification of the Apratoxin Biosynthetic Pathway from a Complex Microbial Assemblage
por: Grindberg, Rashel V., et al.
Publicado: (2011)

Development of Advanced Macrosphelides: Potent Anticancer Agents
por: Paek, Seung-Mann
Publicado: (2015)

Novel Lycorine Derivatives as Anticancer Agents: Synthesis and In Vitro Biological Evaluation
por: Wang, Peng, et al.
Publicado: (2014)

Design, Synthesis, Molecular Docking Study and Biological Evaluation of Novel γ-Carboline Derivatives of Latrepirdine (Dimebon) as Potent Anticancer Agents
por: Voggu, Ramakrishna, et al.
Publicado: (2023)

Comprehensive Review on Betulin as a Potent Anticancer Agent
por: Król, Sylwia Katarzyna, et al.
Publicado: (2015)

Synthesis, Biological Evaluation and Modeling Studies of New Pyrido[3,4-b]indole Derivatives as Broad-Spectrum Potent Anticancer Agents
por: Patil, Shivaputra A, et al.
Publicado: (2017)

Synthesis and Biological Properties of Pyranocoumarin Derivatives as Potent Anti-Inflammatory Agents
por: Min, Su Ji, et al.
Publicado: (2023)

An Improved High Yield Total Synthesis and Cytotoxicity Study of the Marine Alkaloid Neoamphimedine: An ATP-Competitive Inhibitor of Topoisomerase IIα and Potent Anticancer Agent
por: Li, Linfeng, et al.
Publicado: (2014)

Pyridine-Ureas as Potential Anticancer Agents: Synthesis and In Vitro Biological Evaluation
por: El-Naggar, Mohamed, et al.
Publicado: (2018)

Synthesis and Biological Evaluation of Analogs of Didehydroepiandrosterone as Potential New Anticancer Agents
por: J. Solum, Eirik, et al.
Publicado: (2020)

Synthesis and Biological Evaluation of Novel Aminochalcones as Potential Anticancer and Antimicrobial Agents
por: Kozłowska, Joanna, et al.
Publicado: (2019)

Design, Synthesis and Biological Evaluation of Ciprofloxacin- Peptide Conjugates as Anticancer Agents
por: Esfandiari Mazandaran, Kiana, et al.
Publicado: (2019)

Synthesis and Biological Evaluation of New Glycoconjugated LDH Inhibitors as Anticancer Agents †
por: D’Andrea, Felicia, et al.
Publicado: (2019)

Design, Synthesis and Biological Evaluation of New Pyrimidine Derivatives as Anticancer Agents
por: Madia, Valentina Noemi, et al.
Publicado: (2021)

Synthesis and Biological Evaluation of Small Molecules as Potential Anticancer Multitarget Agents
por: Pla-López, Alberto, et al.
Publicado: (2022)

Engineered Bacteriophage T7 as a Potent Anticancer Agent in vivo
por: Hwang, Yoon Jung, et al.
Publicado: (2020)

New pyridine and chromene scaffolds as potent vasorelaxant and anticancer agents
por: Dawood, Dina H., et al.
Publicado: (2021)

Design, Synthesis, and Evaluation of a New Series of Thiazole-Based Anticancer Agents as Potent Akt Inhibitors
por: Altıntop, Mehlika Dilek, et al.
Publicado: (2018)

Synthesis and Biological Activity of trans-Tiliroside Derivatives as Potent Anti-Diabetic Agents
por: Zhu, Yujin, et al.
Publicado: (2010)

Design, Synthesis, and Biological Evaluation of Artemisinin-Indoloquinoline Hybrids as Potent Antiproliferative Agents
por: Wang, Li, et al.
Publicado: (2014)

Identification, synthesis and biological activity of alkyl-guanidine oligomers as potent antibacterial agents
por: Zamperini, C., et al.
Publicado: (2017)

Synthesis and biological evaluation of 2,2-dimethylbenzopyran derivatives as potent neuroprotection agents
por: Du, Fangyu, et al.
Publicado: (2019)

Salinomycin as a potent anticancer stem cell agent: State of the art and future directions
por: Qi, Dan, et al.
Publicado: (2021)

Microwave-assisted one pot three-component synthesis of some novel pyrazole scaffolds as potent anticancer agents
por: Gomha, Sobhi M., et al.
Publicado: (2017)

Potent and Selective Benzothiazole-Based Antimitotics with Improved Water Solubility: Design, Synthesis, and Evaluation as Novel Anticancer Agents
por: Gallego-Yerga, Laura, et al.
Publicado: (2023)

Synthesis and Biological Evaluation of Novel Isoxazole-Amide Analogues as Anticancer and Antioxidant Agents
por: Eid, Ahmad M., et al.
Publicado: (2021)

Novel Pyridothienopyrimidine Derivatives: Design, Synthesis and Biological Evaluation as Antimicrobial and Anticancer Agents
por: Mohi El-Deen, Eman M., et al.
Publicado: (2022)

Design, synthesis and biological evaluation of N-arylsulfonyl carbazoles as novel anticancer agents
por: You, Xin, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_563o0ihkjvumk59akiaciij4rn