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LC–MS Proteomics Analysis of the Insulin/IGF-1-Deficient Caenorhabditis elegans daf-2(e1370) Mutant Reveals Extensive Restructuring of Intermediary Metabolism

[Image: see text] The insulin/IGF-1 receptor is a major known determinant of dauer formation, stress resistance, longevity, and metabolism in Caenorhabditis elegans. In the past, whole-genome transcript profiling was used extensively to study differential gene expression in response to reduced insul...

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Detalles Bibliográficos
Autores principales: Depuydt, Geert, Xie, Fang, Petyuk, Vladislav A., Smolders, Arne, Brewer, Heather M., Camp, David G., Smith, Richard D., Braeckman, Bart P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993954/
https://www.ncbi.nlm.nih.gov/pubmed/24555535
http://dx.doi.org/10.1021/pr401081b