Abacavir Induced T Cell Reactivity from Drug Naïve Individuals Shares Features of Allo-Immune Responses

Abacavir hypersensitivity is a severe hypersensitivity reaction which occurs exclusively in carriers of the HLA-B*57∶01 allele. In vitro culture of PBMC with abacavir results in the outgrowth of abacavir-reacting CD8(+) T cells, which release IFNγ and are cytotoxic. How this immune response is induc...

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Detalles Bibliográficos
Autores principales: Adam, Jacqueline, Wuillemin, Natascha, Watkins, Stephan, Jamin, Heidi, Eriksson, Klara K., Villiger, Peter, Fontana, Stefano, Pichler, Werner J., Yerly, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994040/
https://www.ncbi.nlm.nih.gov/pubmed/24751900
http://dx.doi.org/10.1371/journal.pone.0095339

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994040/
https://www.ncbi.nlm.nih.gov/pubmed/24751900
http://dx.doi.org/10.1371/journal.pone.0095339

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